Modern medicine has evolved rapidly in its theoretical foundations and practical applications. Pertinent historical milestones—from relaxation of dietary restrictions, through organ and cell theory, Copernican revolution, and invention of experimental method, to contemporary scientific developments—serve as markers for understanding how knowledge has been shaped. This heritage continues to influence the design and operation of contemporary health systems.The modern era began with the re-examination of concepts by Anton van Leeuwenhoek, Levi Strauss and John Graham, prior to the establishment of any formal discipline. Development of the discipline of pharmacology followed, and the introduction of the first population-dedicated manual by constituency medicine historian Adolphe Vinchon brought the emergence of Pharmacovigilance, which aimed at assessment of drug-related health factors for population benefits. The establishment of individual autonomy in the mid-twentieth century opened a new approach to modern health systems beyond the conventional orientation towards prevailing norms dominating the societies.
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